MAT Clinics in Mississippi: Methadone, Suboxone & Vivitrol Treatment
Find methadone clinics in Mississippi, compare medication options, and learn how to seek care with or without insurance. Our directory includes 6 opioid treatment program (OTP) locations in 5 cities: 3 Medicare-enrolled locations and 3 additional programs in the Mississippi Department of Mental Health directory. Only 5 of the state’s 82 counties have a listed OTP.
On this page — jump to a section
- Mississippi MAT at a Glance
- Get Help Finding a Clinic
- Find MAT Clinics by City
- MAT Treatment Options by Medication
- Methadone Rules
- Paying for Treatment
- Telehealth MAT
- Opioid Overdose Trends
- Areas with Limited Access
- Mississippi Resources
- Special Populations
- How to Choose a Clinic
- Frequently Asked Questions
- Sources and Editorial Standards
- Nearby States
Mississippi MAT at a Glance
What this means for you: With 77 counties lacking a listed methadone OTP, Mississippi residents may need to compare travel demands with office-based buprenorphine and other care options.
Get Help Finding a Clinic in Mississippi
Need help exploring Mississippi treatment options?
Explore nearby treatment settings, questions to ask about payment, and ways to contact a program directly.
Call 1-(347) 591-7540For an overdose or medical emergency, call 911. For crisis support, call or text 988. SAMHSA National Helpline: 1-800-662-4357.
This is MATClinicGuide’s treatment-navigation line, not a direct number for the clinics listed here. Calls may reach participating providers or navigation partners. MATClinicGuide does not provide medical treatment.
Find MAT Clinics by City in Mississippi
Mississippi has six listed opioid treatment programs across Biloxi, Flowood, Jackson, Meridian and Walls. These entries combine the September 2026 Medicare OTP listing with the Mississippi DMH 2024–25 directory; the labels below distinguish their source and enrollment status.
Top cities for methadone clinics in Mississippi
Mississippi methadone OTP directory: 5 cities
Biloxi — 1 OTP
Biloxi Treatment Center (Metro Treatment of Mississippi LP) MedicareOTP
1989 Pass Rd, Biloxi, MS 39531-4103
Flowood — 1 OTP
Hamilton Davis Mental Health, Inc. DMH-certifiedOTP
2508 Lakeland Drive, Flowood, MS 39232
Jackson — 2 OTPs
Jackson Comprehensive Treatment Center MedicareOTP
1935 Lakeland Dr, Ste 900, Jackson, MS 39216-5028
Alternatives for Life Treatment & Recovery, LLC DMH-certifiedOTP
5360 I-55 N. Frontage Rd, #160, Jackson, MS 39216
Meridian — 1 OTP
Hamilton Davis Mental Health, Inc. DMH-certifiedOTP
2419 10th St, Meridian, MS 39301
Walls — 1 OTP
DeSoto County Treatment Center (Metro Treatment of Mississippi LP) MedicareOTP
8900 Delta Bluff Cv, Walls, MS 38680-4400
Suboxone, buprenorphine and Vivitrol providers in Mississippi
Suboxone doctors in Mississippi and other buprenorphine providers may work in primary-care, psychiatry, and addiction-medicine offices instead of methadone OTPs. For local medication assisted treatment in Mississippi, search by ZIP code at FindTreatment.gov or use the Stand Up, Mississippi treatment center finder. Ask each program which medication it offers, whether it accepts new patients and what insurance it takes.
Listings reflect the CMS OTP file dated September 8, 2026, and the Mississippi DMH 2024–25 directory. Confirm location, intake, operating hours and payment directly with each clinic.
MAT Treatment Options in Mississippi by Medication
Methadone clinics in Mississippi
Methadone for opioid use disorder is provided through certified opioid treatment programs. Mississippi’s six listed OTP locations cluster in the Jackson–Flowood area (three programs), with one each in Biloxi, Meridian and Walls. Early treatment often involves frequent visits for observed medication dosing, making travel a practical factor for people outside those cities. Ask the OTP about intake, guest dosing and any eligibility for take-home medication. Read our methadone treatment guide and OTP explainer.
Buprenorphine / Suboxone in Mississippi
Buprenorphine can be prescribed in office-based care by qualified clinicians, so it may provide an alternative when daily trips to one of Mississippi’s five OTP cities are difficult. Suboxone is a common buprenorphine/naloxone product. People looking for buprenorphine providers in Mississippi can search for practices near their ZIP code and ask whether visits may take place by telehealth under current federal and state requirements. The former federal X-waiver was removed in 2023, but clinicians still must meet applicable prescribing standards. See buprenorphine and Suboxone treatment and MAT versus MOUD.
Long-acting buprenorphine injections: Sublocade and Brixadi
Some Mississippi treatment practices may offer long-acting injectable buprenorphine, which is given by a healthcare professional rather than taken as a daily tablet or film. Sublocade and Brixadi have different dosing schedules and initiation requirements. The six-location OTP directory does not show which Mississippi clinics administer them, so contact an addiction-medicine provider about local availability, clinical suitability and Medicaid or other insurance payment. Injectable treatment can reduce the need to manage a medication every day, but follow-up care remains important. Learn about Sublocade and how long treatment may last.
Naltrexone / Vivitrol in Mississippi
Vivitrol is an extended-release naltrexone injection that blocks opioid effects and is not itself an opioid. A person generally needs an opioid-free period before starting naltrexone because starting too soon can trigger withdrawal. A Mississippi clinician should assess whether this option is appropriate and explain the timing and risks. The Mississippi Medicaid coverage requirement includes medications for opioid use disorder for eligible enrollees, but specific billing and authorization questions depend on the service and plan. See naltrexone and Vivitrol treatment and OUD medication options.
| Medication | Where you get it in Mississippi | Visits at start | Mississippi Medicaid |
|---|---|---|---|
| Methadone | Certified OTP; 6 locations listed | Often frequent, sometimes daily | Covered for eligible enrollees |
| Buprenorphine / Suboxone | Qualified prescribing clinician; some office-based settings | Depends on treatment plan | Covered for eligible enrollees |
| Sublocade / Brixadi | Participating injection provider | Clinician-administered on product schedule | Ask about product and authorization |
| Naltrexone / Vivitrol | Participating prescribing and injection provider | Clinical assessment, then scheduled injection | Covered for eligible enrollees |
Methadone (OTP) Rules in Mississippi
Mississippi’s Department of Mental Health certifies OTPs, which also operate under federal SAMHSA and DEA requirements, including 42 CFR Part 8. The three Medicare-enrolled sites and three additional DMH-certified sites listed above are starting points for questions about intake and dosing.
Starting care at a Mississippi OTP
Contact the Biloxi, Flowood, Jackson, Meridian or Walls program directly to learn its intake process. Ask what identification, insurance or payment information, medication history, and existing treatment records may be useful. Clinical evaluation determines treatment; counseling should be available but is not a prerequisite to starting medication. See medication and counseling.
Take-home doses, guest dosing and transfers
Federal OTP rules updated in 2024 allow clinicians greater flexibility in considering take-home methadone, but decisions are individualized and any applicable Mississippi requirements still apply. For travel or moving between Mississippi communities, ask the clinic about guest dosing or a transfer plan before changing locations. Never assume that a new clinic can immediately continue a prior dosing schedule.
Paying for MAT in Mississippi
Mississippi Medicaid and coverage for OUD medications
Mississippi Medicaid is administered by the Division of Medicaid. Mississippi had not adopted the Affordable Care Act Medicaid expansion as of October 2026, meaning many low-income adults without dependent children may not qualify. For people who are enrolled, federal Medicaid law requires coverage of medications for opioid use disorder, including methadone, buprenorphine and naltrexone. Specific prior authorization and provider-network rules can affect how care is obtained. Visit Mississippi Medicaid to review eligibility and coverage.
| Service | Covered | Notes |
|---|---|---|
| Methadone for OUD | Yes, for enrolled members | Access through participating OTPs; check billing |
| Buprenorphine for OUD | Yes, for enrolled members | Confirm preferred products and pharmacy/provider arrangements |
| Naltrexone for OUD | Yes, for enrolled members | Confirm injection and pharmacy benefits |
| Outpatient substance use care | Check benefits | Service-specific limits vary |
| Residential substance use care | Check benefits | Confirm medical necessity and participating programs |
Medicare
Medicare has an OTP benefit under Part B. In Mississippi, the CMS list dated September 8, 2026 identifies three Medicare-enrolled OTP locations: Biloxi, Jackson Comprehensive Treatment Center and Walls. Medicare drug benefits for office-based buprenorphine and other medications can involve Part D or other applicable coverage, depending on how a medication is provided. Confirm each location’s enrollment and your own benefit details before scheduling.
Private insurance
Private coverage varies by employer, plan, network and the medication prescribed. Federal mental health and substance use parity protections do not mean every provider or formulation is automatically covered. Ask your Mississippi insurer about OTP visits, office-based visits, injection services, deductibles and authorization.
No insurance: treatment payment options
Mississippi’s lack of Medicaid expansion makes uninsured care especially important. The Mississippi Department of Mental Health and its 24/7 helpline (1-877-210-8513) can connect callers with treatment and recovery resources. Ask local community mental health centers about available services, clinics about self-pay or sliding-scale policies, and whether a Marketplace plan may be an option. See MAT cost and insurance, insurance coverage and insurance verification.
Need help comparing Mississippi treatment options?
Explore nearby treatment settings, questions to ask about payment, and ways to contact a program directly.
Call 1-(347) 591-7540For an overdose or medical emergency, call 911. For crisis support, call or text 988. SAMHSA National Helpline: 1-800-662-4357.
This is MATClinicGuide’s treatment-navigation line, not a direct number for the clinics listed here. Calls may reach participating providers or navigation partners. MATClinicGuide does not provide medical treatment.
Telehealth MAT in Mississippi
Telehealth Suboxone in Mississippi may be possible through a qualified prescriber operating under federal and Mississippi requirements; it is not a guaranteed option for every patient or prescription. Federal DEA/HHS controlled-medication telemedicine flexibilities are in effect through December 31, 2026, although requirements and extensions can change. Ask a Mississippi provider how the initial evaluation, follow-up visits, pharmacies, and any in-person requirements are handled.
Methadone for opioid use disorder remains tied to certified OTP dispensing and oversight; a video visit does not turn a remote practice into a methadone clinic. For residents of the Delta, Northeast Mississippi or the Pine Belt, telehealth may reduce some follow-up travel for office-based care. See telehealth MAT.
Opioid Overdose in Mississippi: Why Access Matters
Mississippi recorded 525 drug overdose deaths in 2024, with an age-adjusted all-drug overdose death rate of 18.6 per 100,000, according to CDC NCHS data reported by KFF and USAFacts. This was below the U.S. rate of 23.1 that year, but the state’s small network of methadone OTPs still creates major geographic access challenges.
The Mississippi all-drug rate rose from 13.6 in 2019 to 28.4 in 2021 before falling to 18.6 in 2024. The opioid-specific death rate likewise moved from 8.5 in 2019 to 20.3 in 2021 and 11.0 in 2024 (CDC/KFF). These figures describe population trends, not what will happen to any individual person.
| Year | Mississippi all-drug rate | Mississippi opioid rate | U.S. all-drug rate |
|---|---|---|---|
| 2019 | 13.6 | 8.5 | — |
| 2020 | 21.1 | 14.6 | — |
| 2021 | 28.4 | 20.3 | — |
| 2022 | 27.6 | 20.0 | 32.6 |
| 2023 | 25.3 | 18.1 | 31.3 |
| 2024 | 18.6 | 11.0 | 23.1 |
Mississippi’s access map points to the importance of nearby medication options and overdose-reversal support. Learn how naloxone works and request free Narcan through Stand Up, Mississippi.
Areas of Mississippi with Limited MAT Access
Seventy-seven of Mississippi’s 82 counties have no OTP among the six programs in this directory. The nearest-city suggestions below are geographic starting points, not confirmed closest facilities for every address; compare routes and intake availability before travel. Office-based buprenorphine and appropriate telehealth services may help when daily methadone travel is not practical.
Mississippi Delta
Counties and communities: Washington (Greenville), Bolivar (Cleveland), Sunflower, Leflore (Greenwood), Coahoma (Clarksdale) and Tunica counties. Nearest OTP cities to explore: Walls or Jackson.
Northeast Mississippi
Counties and communities: Lee (Tupelo), Lowndes (Columbus), Oktibbeha (Starkville), Lafayette (Oxford) and Alcorn (Corinth) counties. Nearest OTP cities to explore: Walls or Meridian.
Pine Belt and Southeast Mississippi
Counties and communities: Forrest (Hattiesburg), Jones (Laurel), Lamar, Wayne, Jackson (Pascagoula), Hancock and Pearl River counties. Nearest OTP cities to explore: Biloxi, Meridian, Jackson or Flowood.
Southwest Mississippi
Counties and communities: Adams (Natchez), Pike (McComb), Lincoln (Brookhaven), Copiah and Warren (Vicksburg) counties. Nearest OTP cities to explore: Jackson or Flowood.
Central Mississippi outside Jackson
Counties and communities: Madison, Scott, Leake, Neshoba, Attala and Yazoo counties. Nearest OTP cities to explore: Jackson, Flowood or Meridian.
Across these regions, the 24/7 Mississippi DMH Helpline can guide people toward local services, and Stand Up, Mississippi provides naloxone access information. Families may also find guidance on helping a loved one useful.
Mississippi Resources & Helplines
Mississippi Department of Mental Health
1101 Robert E. Lee Building, 239 North Lamar St., Jackson, MS 39201. (601) 359-1288. DMH website
DMH Helpline
1-877-210-8513, available 24/7 for alcohol and drug treatment and recovery support.
Stand Up, Mississippi
Find DMH-certified treatment options, a naloxone locator, and free Narcan requests for individuals. Visit Stand Up, Mississippi
Mississippi Medicaid
Division of Medicaid information about eligibility, enrollment and benefits. Visit Mississippi Medicaid
Naloxone and overdose protections in Mississippi
Stand Up, Mississippi offers free Narcan requests for individuals and a naloxone locator; a free naloxone vending machine at Jackson Medical Mall provides 24/7 access. Mississippi HB 692 (2015) permits naloxone prescribing, dispensing and good-faith administration under stated conditions. Naloxone is also available over the counter.
Mississippi’s Good Samaritan provision, Miss. Code § 41-29-149.1, provides limited protections for people who seek medical assistance in good faith during an overdose, including specified low-level drug-possession offenses when evidence arises from the help-seeking event. It does not protect every offense. Call 911 immediately if someone may be overdosing.
MAT for Special Populations in Mississippi
Pregnant and postpartum people
Pregnant Mississippi residents with opioid use disorder should seek prompt care from a pregnancy clinician and an OUD treatment specialist. Medication decisions need individualized medical assessment; stopping opioids abruptly without professional guidance can be risky. Ask the Mississippi DMH Helpline which programs can coordinate prenatal, postpartum and addiction care. A clinic can explain whether methadone or buprenorphine is appropriate, where dosing occurs, and how continuity after delivery is arranged.
Veterans
Veterans in Mississippi can ask a VA care team about evaluation for medication treatment of opioid use disorder and connections to community programs. The six OTPs listed above are civilian locations and should not be mistaken for a VA-specific treatment directory. Veterans in remote areas may want to discuss transportation, care coordination, and whether office-based follow-up is possible. Tell both the VA and any civilian prescriber about current medications to help prevent gaps in care.
Adolescents and young adults
Young people in Mississippi may require age-specific assessment, consent procedures and a program equipped for their circumstances. The state DMH Helpline offers a starting point for locating appropriate substance use services. Families should ask about clinician experience with adolescents, medication eligibility, privacy, and ways caregivers can participate in support when appropriate. Decisions about MOUD should be based on age, clinical needs, and applicable requirements rather than assumptions about what younger patients need.
People leaving jail or prison
For someone preparing to return to a Mississippi community after incarceration, medication continuity and a practical first appointment can be important. Ask the discharge planner and a community treatment provider to coordinate records, prescriptions when appropriate, insurance questions and overdose-prevention supplies. The DMH Helpline can help identify local services. Returning residents outside the five listed OTP cities may need an additional discussion about transportation and alternatives for ongoing follow-up.
Rural residents
Residents of the Delta, Pine Belt, Southwest and Northeast Mississippi face longer potential trips because 77 counties do not appear on the state’s six-location OTP list. Compare office-based buprenorphine, qualified telehealth care, local counseling support if desired, and the travel schedule for methadone before selecting a program. Free Narcan access through Stand Up, Mississippi can add an overdose-prevention resource while someone seeks treatment.
How to Choose a MAT Clinic in Mississippi
Choosing a Mississippi treatment program starts with the medication that fits your medical needs and the travel you can manage. A person in Jackson may have several OTP choices, while someone in Greenville or Hattiesburg may need to evaluate a longer drive or office-based care.
Questions to ask before you call
For methadone OTPs:
- Are you accepting new patients, and how is intake scheduled?
- What is the expected visit and dosing schedule at the start?
- Do you accept Mississippi Medicaid, Medicare, or my private plan?
- What are self-pay fees, and are take-home or guest-dosing options available?
- If I travel from another county, how are missed trips or transfers handled?
For buprenorphine and other medication providers:
- Do you prescribe buprenorphine or offer Vivitrol or injectable buprenorphine?
- Are telehealth visits possible under current requirements?
- Which pharmacies and insurance plans do you work with?
- What happens after the first prescription, and how are follow-ups arranged?
- Can you coordinate care with a primary-care doctor or pregnancy clinician if needed?
What happens at the first visit?
- Discuss substance use history, health concerns and current medicines with a qualified clinician.
- Review medication choices, potential withdrawal concerns and the treatment plan.
- Go over dosing, follow-up appointments, payment and transportation.
- Ask how to obtain naloxone and whom to contact with urgent treatment questions.
For practical questions about starting or continuing medication, see treatment duration and counseling and MOUD.
Need help finding a place to start?
Explore nearby treatment settings, questions to ask about payment, and ways to contact a program directly.
Call 1-(347) 591-7540For an overdose or medical emergency, call 911. For crisis support, call or text 988. SAMHSA National Helpline: 1-800-662-4357.
This is MATClinicGuide’s treatment-navigation line, not a direct number for the clinics listed here. Calls may reach participating providers or navigation partners. MATClinicGuide does not provide medical treatment.
FAQs About MAT Clinics in Mississippi
How many methadone clinics are in Mississippi?
Our Mississippi directory lists six OTP locations across five cities: two in Jackson and one each in Biloxi, Flowood, Meridian and Walls. Three appear in the CMS Medicare enrollment file dated September 8, 2026, and three more in the Mississippi DMH 2024–25 directory. Use the city directory above to review contact information.
Does Mississippi Medicaid cover Suboxone and methadone?
Yes, federal Medicaid law requires coverage of OUD medications, including buprenorphine products such as Suboxone, methadone and naltrexone, for enrolled Mississippi Medicaid members. Eligibility is a separate question because Mississippi had not expanded Medicaid as of October 2026. Ask the Division of Medicaid and your treatment provider about the medication, program and authorization process.
Are there free methadone clinics in Mississippi?
No specific clinic in this six-location directory is identified as providing free methadone treatment. People without insurance can ask each OTP about self-pay charges or assistance. The Mississippi DMH Helpline at 1-877-210-8513 can help callers explore public treatment and recovery resources. Do not assume that a Medicare-enrolled OTP offers free care.
Which Mississippi cities have opioid treatment programs?
The listed opioid treatment programs in Mississippi are in Biloxi, Flowood, Jackson, Meridian and Walls. Jackson has two; the other four cities have one each. Together, those locations are in five counties: Harrison, Rankin, Hinds, Lauderdale and DeSoto. Residents elsewhere should compare travel needs with office-based options and call ahead about intake.
Can I get telehealth Suboxone in Mississippi?
Telehealth buprenorphine care may be available through appropriately qualified prescribers, subject to Mississippi and federal rules and clinical judgment. Federal controlled-medication telemedicine flexibilities run through December 31, 2026 under the policy noted here. Ask a clinician whether remote assessment is appropriate and whether any in-person visit, pharmacy arrangement or follow-up is needed.
Where can I find Suboxone doctors in Mississippi?
Search FindTreatment.gov using your ZIP code, or use Stand Up, Mississippi’s treatment center finder. Office-based buprenorphine may be offered in primary-care, psychiatry or addiction-medicine practices and need not be located at one of the six listed methadone OTPs. Confirm a practice offers medication for opioid use disorder, accepts new patients and works with your coverage.
Does Mississippi have Vivitrol treatment?
Naltrexone, including extended-release Vivitrol, is one of the medication options for opioid use disorder. Availability at a specific Mississippi practice is not established by the state OTP directory. Ask a qualified provider whether it offers the injection and what opioid-free period or medical assessment is needed before starting. Medicaid coverage questions should be addressed with the provider and payer.
Where can I get Narcan for free in Mississippi?
Stand Up, Mississippi provides a free Narcan request option for individuals and a naloxone locator. The Jackson Medical Mall also has a free naloxone vending machine with 24/7 access. Naloxone can reverse an opioid overdose; call 911 immediately for a suspected overdose even if naloxone has been given.
What if my Mississippi county has no methadone clinic?
Seventy-seven of Mississippi’s 82 counties have no location in this six-OTP directory. Depending on where you live, Jackson, Flowood, Biloxi, Meridian or Walls may be places to explore. An office-based buprenorphine practice, appropriate telehealth care, or assistance through the 24/7 DMH Helpline may offer a more manageable path to assessment.
Does Mississippi have a Good Samaritan law for overdose calls?
Yes. Miss. Code § 41-29-149.1, enacted under HB 692 in 2015, offers limited protections when someone seeks medical assistance in good faith for an overdose, including specified low-level drug violations arising from that call for help. It is not blanket immunity from all offenses. In an overdose emergency, call 911 immediately.
Sources, Methodology & Editorial Standards
- CMS Medicare OTP Providers, September 8, 2026
- Mississippi DMH Alcohol and Drug Services Directory, 2024–25
- Mississippi Department of Mental Health, agency and helpline
- DMH overdose awareness resources
- Stand Up, Mississippi, treatment and naloxone resources
- Mississippi HB 692 (2015), naloxone and Good Samaritan protections
- KFF Medicaid expansion status, October 2026
- KFF / CDC opioid overdose death rates, through 2024
- USAFacts / CDC Mississippi overdose deaths, through 2024
- Mississippi Division of Medicaid
The clinic directory brings together the CMS Medicare-enrolled opioid treatment program file dated September 8, 2026, and the Mississippi DMH 2024–25 directory. Matching locations were counted once; Medicare enrollment and DMH-certified entries are labeled separately. Population rates come from CDC-related reporting and refer to the years shown. MATClinicGuide.com neither owns nor operates the listed clinics.
This page offers educational and treatment-navigation information, not a medical diagnosis, prescription or treatment recommendation. Clinical decisions, appointment availability, eligibility and payment should be confirmed with a qualified provider. MATClinicGuide’s telephone line is separate from the listed clinics and may be answered by or routed to participating treatment providers or navigation partners. In an emergency, call 911; for mental health crisis support, call or text 988.
Read our editorial policy, medical disclaimer and advertising and referral disclosure.
MAT Clinics in Nearby States
Explore medication treatment options in neighboring states if your care plan or travel needs involve locations beyond Mississippi. Confirm each provider’s eligibility and intake requirements directly.